Biomonitoring of Di-(2-Ethylhexyl) Phthalate (DEHP) Exposure in Human

Teratogenicity of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) in mice.

Di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DBP) were mixed with diet at graded levels of 0.05, 0.1, 0.2. 0.4 and 1.0 wt-% and given to pregnant ICR mice throughout gestation. Maternal weight gain was suppressed and fetal resorption increased at 0.2, 0.4 and 1.0% levels of DEHP and 1.0% level of DBP. All the implanted ova died early in rats fed 0.4 and 1.0% levels of DEHP. Exter...

Toxicological Profile for Di-(2-ethylhexyl) Phthalate (dehp)

Migration of di-(2-ethylhexyl)phthalate (DEHP) and diisononyl phthalate (DINP) from PVC articles

Zusammenfassung DEHP und DINP sind Primärweichmacher, die in vielen Weich-PVC-Artikeln wie Beißringen für Kleinkinder eingesetzt werden. Die Ultraschallbad-Extraktion scheint gut geeignet zur Bestimmung der Migration von Phthalaten aus Kunststoff-Gegenständen und liefert Werte, wie sie auch beim Saugen mit Testpersonen erhalten worden waren. Die höheren Migrationsraten, die beim Kauen der Kunst...

NTP Research Concept: Di(2-ethylhexyl) Phthalate (DEHP) and Phthalate Mixtures

program prior to designing and conducting toxicology studies. The purpose of the research concept document is to outline the general elements of a research program that would address the specific public health concerns that prompted the nomination of the substance or issue for study. It may also encompass substance-specific studies that address larger public health issues or topics in toxicolog...

Reversibility and persistence of di-2-ethylhexyl phthalate (DEHP)- and phenobarbital-induced hepatocellular changes in rodents.

The tumor promotion stage of chemical carcinogenesis has been shown to exhibit a persistence of cellular effects during treatment and the reversibility of these changes upon cessation of treatment. Inhibition of gap-junctional intercellular communication and increased replicative DNA synthesis appear to be important in this process. The present study assessed the persistence and reversibility o...